Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers
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چکیده
منابع مشابه
Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.
Aberrant activation of mast cells contributes to the development of numerous diseases including cancer, autoimmune disorders, as well as diabetes and its complications. The influx of extracellular calcium via the highly calcium selective calcium-release activated calcium (CRAC) channel controls mast cell functions. Intracellular calcium homeostasis in mast cells can be maintained via the modula...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2017
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2016.12.062